Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice

Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking the viru...

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Vydáno v:PLoS Pathog
Hlavní autoři: Martinot, Amanda J., Blass, Eryn, Yu, Jingyou, Aid, Malika, Mahrokhian, Shant H., Cohen, Sara B., Plumlee, Courtney R., Larocca, Rafael A., Siddiqi, Noman, Wakabayashi, Shoko, Gardner, Michelle, Audette, Rebecca, Devorak, Anne, Urdahl, Kevin B., Rubin, Eric J., Barouch, Dan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769599/
https://ncbi.nlm.nih.gov/pubmed/33315936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009096
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