Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice

Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking the viru...

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發表在:PLoS Pathog
Main Authors: Martinot, Amanda J., Blass, Eryn, Yu, Jingyou, Aid, Malika, Mahrokhian, Shant H., Cohen, Sara B., Plumlee, Courtney R., Larocca, Rafael A., Siddiqi, Noman, Wakabayashi, Shoko, Gardner, Michelle, Audette, Rebecca, Devorak, Anne, Urdahl, Kevin B., Rubin, Eric J., Barouch, Dan H.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769599/
https://ncbi.nlm.nih.gov/pubmed/33315936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009096
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