Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice

Bacille Calmette-Guerin (BCG), an attenuated whole cell vaccine based on Mycobacterium bovis, is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), but its efficacy is suboptimal and it fails to protect against pulmonary tuberculosis. We previously reported that Mtb lacking the viru...

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Pubblicato in:PLoS Pathog
Autori principali: Martinot, Amanda J., Blass, Eryn, Yu, Jingyou, Aid, Malika, Mahrokhian, Shant H., Cohen, Sara B., Plumlee, Courtney R., Larocca, Rafael A., Siddiqi, Noman, Wakabayashi, Shoko, Gardner, Michelle, Audette, Rebecca, Devorak, Anne, Urdahl, Kevin B., Rubin, Eric J., Barouch, Dan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769599/
https://ncbi.nlm.nih.gov/pubmed/33315936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009096
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