Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to intracellular triacylglyceride (TAG) accumulation, an...

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Detalles Bibliográficos
Publicado en:PLoS Pathog
Main Authors: Martinot, Amanda J., Farrow, Mary, Bai, Lu, Layre, Emilie, Cheng, Tan-Yun, Tsai, Jennifer H., Iqbal, Jahangir, Annand, John W., Sullivan, Zuri A., Hussain, M. Mahmood, Sacchettini, James, Moody, D. Branch, Seeliger, Jessica C., Rubin, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709180/
https://ncbi.nlm.nih.gov/pubmed/26751071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005351
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