Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2

Knockout of lprG results in decreased virulence of Mycobacterium tuberculosis (Mtb) in mice. Mtb lipoprotein LprG has TLR2 agonist activity, thought to be dependent on its N-terminal triacylation. Surprisingly, here we find that non-acylated LprG retains TLR2 activity. Moreover, we show LprG associa...

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Detalhes bibliográficos
Main Authors: Drage, Michael G., Tsai, Han-Chun, Pecora, Nicole D., Cheng, Tan-Yun, Arida, Ahmad R., Shukla, Supriya, Rojas, Roxana E., Seshadri, Chetan, Moody, D. Branch, Boom, W. Henry, Sacchettini, James C., Harding, Clifford V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933325/
https://ncbi.nlm.nih.gov/pubmed/20694006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1869
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