Mycobacterium tuberculosis Lipoprotein LprG Binds Lipoarabinomannan and Determines Its Cell Envelope Localization to Control Phagolysosomal Fusion

Mycobacterium tuberculosis (Mtb) virulence is decreased by genetic deletion of the lipoprotein LprG, but the function of LprG remains unclear. We report that LprG expressed in Mtb binds to lipoglycans, such as lipoarabinomannan (LAM), that mediate Mtb immune evasion. Lipoglycan binding to LprG was d...

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Detalhes bibliográficos
Main Authors: Shukla, Supriya, Richardson, Edward T., Athman, Jaffre J., Shi, Libin, Wearsch, Pamela A., McDonald, David, Banaei, Niaz, Boom, W. Henry, Jackson, Mary, Harding, Clifford V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214796/
https://ncbi.nlm.nih.gov/pubmed/25356793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004471
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