Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers

Immunodominance to nonneutralizing epitopes is a roadblock in designing vaccines against several diseases of high interest. One hypothetical possibility is that limited CD4 T cell help to B cells in a normal germinal center (GC) response results in selective recruitment of abundant, immunodominant B...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Lee, Jeong Hyun, Hu, Joyce K., Georgeson, Erik, Nakao, Catherine, Groschel, Bettina, Dileepan, Thamotharampillai, Jenkins, Marc K., Seumois, Gregory, Vijayanand, Pandurangan, Schief, William R., Crotty, Shane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769167/
https://ncbi.nlm.nih.gov/pubmed/33355623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201254
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