Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α-synuclein are, indeed, involved in type-II diabetes, Alzheimer’s, and Parkinson’s, respectively. Despite the correlation of th...

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Udgivet i:ACS Chem Neurosci
Main Authors: Sciacca, Michele F., Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R., Watson, Matthew D., García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C., Ramamoorthy, Ayyalusamy, La Rosa, Carmelo
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769131/
https://ncbi.nlm.nih.gov/pubmed/33269918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00588
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