Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding

Binding of the intracellular adapter proteins talin and its cofactor, kindlin, to the integrin receptors induces integrin activation and clustering. These processes are essential for cell adhesion, migration, and organ development. Although the talin head, the integrin-binding segment in talin, poss...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Zhang, Pingfeng, Azizi, Latifeh, Kukkurainen, Sampo, Gao, Tong, Baikoghli, Mo, Jacquier, Marie-Claude, Sun, Yijuan, Määttä, Juha A. E., Cheng, R. Holland, Wehrle-Haller, Bernhard, Hytönen, Vesa P., Wu, Jinhua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768682/
https://ncbi.nlm.nih.gov/pubmed/33288722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014583117
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