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Engineering an Effective Human SNAP-23 Cleaving Botulinum Neurotoxin A Variant

Botulinum neurotoxin (BoNT) serotype A inhibits neurotransmitter release by cleaving SNAP-25 and represents an established pharmaceutical for treating medical conditions caused by hyperactivity of cholinergic nerves. Oversecretion from non-neuronal cells is often also the cause of diseases. Notably,...

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Podrobná bibliografie
Vydáno v:Toxins (Basel)
Hlavní autoři: Sikorra, Stefan, Donald, Sarah, Elliott, Mark, Schwede, Susan, Coker, Shu-Fen, Kupinski, Adam P., Tripathi, Vineeta, Foster, Keith, Beard, Matthew, Binz, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766560/
https://ncbi.nlm.nih.gov/pubmed/33352834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12120804
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