Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission

Botulinum neurotoxin serotype C (BoNT/C) is a neuroparalytic toxin associated with outbreaks of animal botulism, particularly in birds, and is the only BoNT known to cleave two different SNARE proteins, SNAP-25 and syntaxin. BoNT/C was shown to be a good substitute for BoNT/A1 in human dystonia ther...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zanetti, Giulia, Sikorra, Stefan, Rummel, Andreas, Krez, Nadja, Duregotti, Elisa, Negro, Samuele, Henke, Tina, Rossetto, Ornella, Binz, Thomas, Pirazzini, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568444/
https://ncbi.nlm.nih.gov/pubmed/28800600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006567
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