Androgens Accentuate TGF‐β Dependent Erk/Smad Activation During Thoracic Aortic Aneurysm Formation in Marfan Syndrome Male Mice

BACKGROUND: Male patients with Marfan syndrome have a higher risk of aortic events and root dilatation compared with females. The role androgens play during Marfan syndrome aneurysm development in males remains unknown. We hypothesized that androgens potentiate transforming growth factor beta induce...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Tashima, Yasushi, He, Hao, Cui, Jason Z., Pedroza, Albert J., Nakamura, Ken, Yokoyama, Nobu, Iosef, Cristiana, Burdon, Grayson, Koyano, Tiffany, Yamaguchi, Atsushi, Fischbein, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763370/
https://ncbi.nlm.nih.gov/pubmed/33059492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015773
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