Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting

Cancer cachexia is characterized by reductions in peripheral lean muscle mass. Prior studies have primarily focused on increased protein breakdown as the driver of cancer-associated muscle wasting. Therapeutic interventions targeting catabolic pathways have, however, largely failed to preserve muscl...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kunz, Hawley E., Dorschner, Jessica M., Berent, Taylor E., Meyer, Thomas, Wang, Xuewei, Jatoi, Aminah, Kumar, Rajiv, Lanza, Ian R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762938/
https://ncbi.nlm.nih.gov/pubmed/33453990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014884
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