Cargando...
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation
Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleus, c...
Guardado en:
| Publicado en: | J Biol Chem |
|---|---|
| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7762928/ https://ncbi.nlm.nih.gov/pubmed/33453989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015800 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|