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Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation

Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleus, c...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Nandi, Suparno, Razzaghi, Mortezaali, Srivastava, Dhiraj, Dey, Mishtu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762928/
https://ncbi.nlm.nih.gov/pubmed/33453989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015800
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