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Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation
Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/monomeric form that translocates into the nucleus, c...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7762928/ https://ncbi.nlm.nih.gov/pubmed/33453989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015800 |
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