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Structural basis of allosteric regulation of Tel1/ATM kinase
ATM/Tel1 is an apical kinase that orchestrates the multifaceted DNA damage response. Mutations of ATM/Tel1 are associated with ataxia telangiectasia syndrome. Here, we report cryo-EM structures of symmetric dimer (4.1 Å) and asymmetric dimer (4.3 Å) of Saccharomyces cerevisiae Tel1. In the symmetric...
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| Publicado no: | Cell Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6796912/ https://ncbi.nlm.nih.gov/pubmed/31097817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0176-1 |
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