Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation. Specifically, they over-express the M2 isoform of the tightly regulated enzyme pyruvate kinase (PKM2), which controls glycolytic flux, and they are highly dependent on de novo biosynthesis o...

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Autores principales: Chaneton, Barbara, Hillmann, Petra, Zheng, Liang, Martin, Agnès C.L., Maddocks, Oliver D.K., Chokkathukalam, Achuthanunni, Coyle, Joseph E, Jankevics, Andris, Holding, Finn P., Vousden, Karen H., Frezza, Christian, O’Reilly, Marc, Gottlieb, Eyal
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894725/
https://ncbi.nlm.nih.gov/pubmed/23064226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11540
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