Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR

Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely used to treat asthma disorders, while CysLT2R is a po...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Sadybekov, Arman A., Brouillette, Rebecca L., Marin, Egor, Sadybekov, Anastasiia V., Luginina, Aleksandra, Gusach, Anastasiia, Mishin, Alexey, Besserer-Offroy, Élie, Longpré, Jean-Michel, Borshchevskiy, Valentin, Cherezov, Vadim, Sarret, Philippe, Katritch, Vsevolod
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761830/
https://ncbi.nlm.nih.gov/pubmed/33287369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10121634
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