Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Cysteinyl leukotriene G protein-coupled receptors CysLT(1) and CysLT(2) regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT(1)R has been used for treating asthma and associated diseases for over two decades, CysLT(2)R has recently started to em...

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Publié dans:Nat Commun
Auteurs principaux: Gusach, Anastasiia, Luginina, Aleksandra, Marin, Egor, Brouillette, Rebecca L., Besserer-Offroy, Élie, Longpré, Jean-Michel, Ishchenko, Andrii, Popov, Petr, Patel, Nilkanth, Fujimoto, Taku, Maruyama, Toru, Stauch, Benjamin, Ergasheva, Margarita, Romanovskaia, Daria, Stepko, Anastasiia, Kovalev, Kirill, Shevtsov, Mikhail, Gordeliy, Valentin, Han, Gye Won, Katritch, Vsevolod, Borshchevskiy, Valentin, Sarret, Philippe, Mishin, Alexey, Cherezov, Vadim
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897958/
https://ncbi.nlm.nih.gov/pubmed/31811124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13348-2
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