Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

The G protein–coupled cysteinyl leukotriene receptor CysLT(1)R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT(1)R antagonists are widely prescribed as antiasthmatic drugs; however,...

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Publicado en:Sci Adv
Main Authors: Luginina, Aleksandra, Gusach, Anastasiia, Marin, Egor, Mishin, Alexey, Brouillette, Rebecca, Popov, Petr, Shiriaeva, Anna, Besserer-Offroy, Élie, Longpré, Jean-Michel, Lyapina, Elizaveta, Ishchenko, Andrii, Patel, Nilkanth, Polovinkin, Vitaly, Safronova, Nadezhda, Bogorodskiy, Andrey, Edelweiss, Evelina, Hu, Hao, Weierstall, Uwe, Liu, Wei, Batyuk, Alexander, Gordeliy, Valentin, Han, Gye Won, Sarret, Philippe, Katritch, Vsevolod, Borshchevskiy, Valentin, Cherezov, Vadim
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785256/
https://ncbi.nlm.nih.gov/pubmed/31633023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2518
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