Neuroprotective Effects of the Anti-cancer Drug Lapatinib Against Epileptic Seizures via Suppressing Glutathione Peroxidase 4-Dependent Ferroptosis

Epilepsy is a complex neurological disorder characterized by recurrent and unprovoked seizures. Neuronal death process is implicated in the development of repetitive epileptic seizures. Therefore, cell death can be harnessed for ceasing seizures and epileptogenesis. Oxidative stress is regarded as a...

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Pubblicato in:Front Pharmacol
Autori principali: Jia, Ji-Ning, Yin, Xi-Xi, Li, Qin, Guan, Qi-Wen, Yang, Nan, Chen, Kang-Ni, Zhou, Hong-Hao, Mao, Xiao-Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758233/
https://ncbi.nlm.nih.gov/pubmed/33362556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.601572
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