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Neuroprotective Effects of the Anti-cancer Drug Lapatinib Against Epileptic Seizures via Suppressing Glutathione Peroxidase 4-Dependent Ferroptosis

Epilepsy is a complex neurological disorder characterized by recurrent and unprovoked seizures. Neuronal death process is implicated in the development of repetitive epileptic seizures. Therefore, cell death can be harnessed for ceasing seizures and epileptogenesis. Oxidative stress is regarded as a...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Jia, Ji-Ning, Yin, Xi-Xi, Li, Qin, Guan, Qi-Wen, Yang, Nan, Chen, Kang-Ni, Zhou, Hong-Hao, Mao, Xiao-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758233/
https://ncbi.nlm.nih.gov/pubmed/33362556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.601572
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