Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand

Quality control of monoclonal antibodies is challenging due in part to the diversity of post‐translational modifications present. The regulation of the N‐glycans of IgG‐Fc domain is one of the key factors to maintain the safety and efficacy of antibody drugs. The FcγRIIIa affinity column is an attra...

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Dades bibliogràfiques
Publicat a:Biotechnol Prog
Autors principals: Kosuge, Hirofumi, Nagatoishi, Satoru, Kiyoshi, Masato, Ishii‐Watabe, Akiko, Tanaka, Toru, Terao, Yosuke, Oe, Seigo, Ide, Teruhiko, Tsumoto, Kouhei
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Inc. 2020
Matèries:
RESEARCH ARTICLES
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757244/
https://ncbi.nlm.nih.gov/pubmed/32390308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.3016
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