Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis

BCR-ABL, an oncogenic fusion gene, plays a central role in the pathogenesis of chronic myeloid leukemia (CML). Oncogenic signaling induces oncogene-induced senescence and senescence-associated secretory phenotype (SASP), which is characterized by enhanced production of various cytokines. BCR-ABL gen...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Tanabe, Yamato, Kawamoto, Shimpei, Takaku, Tomoiku, Morishita, Soji, Hirao, Atsushi, Komatsu, Norio, Hara, Eiji, Mukaida, Naofumi, Baba, Tomohisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757005/
https://ncbi.nlm.nih.gov/pubmed/33351113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003117
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