Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis

BCR-ABL, an oncogenic fusion gene, plays a central role in the pathogenesis of chronic myeloid leukemia (CML). Oncogenic signaling induces oncogene-induced senescence and senescence-associated secretory phenotype (SASP), which is characterized by enhanced production of various cytokines. BCR-ABL gen...

詳細記述

保存先:
書誌詳細
出版年:Blood Adv
主要な著者: Tanabe, Yamato, Kawamoto, Shimpei, Takaku, Tomoiku, Morishita, Soji, Hirao, Atsushi, Komatsu, Norio, Hara, Eiji, Mukaida, Naofumi, Baba, Tomohisa
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2020
主題:
Myeloid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757005/
https://ncbi.nlm.nih.gov/pubmed/33351113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003117
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