Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiological roles of cytoplasmic DNAs in leukemias remain largely un...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Baba, Tomohisa, Yoshida, Takeshi, Tanabe, Yamato, Nishimura, Tatsunori, Morishita, Soji, Gotoh, Noriko, Hirao, Atsushi, Hanayama, Rikinari, Mukaida, Naofumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997981/
https://ncbi.nlm.nih.gov/pubmed/33771977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03587-x
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