Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiological roles of cytoplasmic DNAs in leukemias remain largely un...

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Publicat a:Cell Death Dis
Autors principals: Baba, Tomohisa, Yoshida, Takeshi, Tanabe, Yamato, Nishimura, Tatsunori, Morishita, Soji, Gotoh, Noriko, Hirao, Atsushi, Hanayama, Rikinari, Mukaida, Naofumi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997981/
https://ncbi.nlm.nih.gov/pubmed/33771977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03587-x
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