Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or radiotherapy-mediated DNA damage response and replication stress. However, the pathophysiological roles of cytoplasmic DNAs in leukemias remain largely un...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Baba, Tomohisa, Yoshida, Takeshi, Tanabe, Yamato, Nishimura, Tatsunori, Morishita, Soji, Gotoh, Noriko, Hirao, Atsushi, Hanayama, Rikinari, Mukaida, Naofumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997981/
https://ncbi.nlm.nih.gov/pubmed/33771977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03587-x
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