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Improving the Stability of Maleimide–Thiol Conjugation for Drug Targeting
Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overco...
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| Publicado en: | Chemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7756610/ https://ncbi.nlm.nih.gov/pubmed/32871016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003951 |
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