A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt(IV) Complexes under Physiological Conditions

Due to their high kinetic inertness and consequently reduced side reactions with biomolecules, Pt(IV) complexes are considered to define the future of anticancer platinum drugs. The aqueous stability of a series of biscarboxylato Pt(IV) complexes was studied under physiologically relevant conditions...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Kastner, Alexander, Poetsch, Isabella, Mayr, Josef, Burda, Jaroslav V., Roller, Alexander, Heffeter, Petra, Keppler, Bernhard K., Kowol, Christian R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766845/
https://ncbi.nlm.nih.gov/pubmed/30870571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900682
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