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Improving the Stability of Maleimide–Thiol Conjugation for Drug Targeting

Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overco...

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Vydáno v:Chemistry
Hlavní autoři: Lahnsteiner, Marianne, Kastner, Alexander, Mayr, Josef, Roller, Alexander, Keppler, Bernhard K., Kowol, Christian R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756610/
https://ncbi.nlm.nih.gov/pubmed/32871016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003951
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