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Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib

Tyrosine kinase inhibitors revolutionized cancer therapy but still evoke strong adverse effects that can dramatically reduce patients’ quality of life. One possibility to enhance drug safety is the exploitation of prodrug strategies to selectively activate a drug inside the tumor tissue. In this stu...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Bielec, Bjoern, Poetsch, Isabella, Ahmed, Esra, Heffeter, Petra, Keppler, Bernhard K., Kowol, Christian R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179202/
https://ncbi.nlm.nih.gov/pubmed/32143435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25051149
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