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Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

Intracellular generation of reactive oxygen species (ROS) via thiol-mediated reduction of copper(II) to copper(I) has been assumed as the major mechanism underlying the anticancer activity of copper(II) complexes. The aim of this study was to compare the anticancer potential of copper(II) complexes...

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Detalhes bibliográficos
Main Authors: Kowol, Christian R., Heffeter, Petra, Miklos, Walter, Gille, Lars, Trondl, Robert, Cappellacci, Loredana, Berger, Walter, Keppler, Bernhard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371635/
https://ncbi.nlm.nih.gov/pubmed/22189939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-011-0864-x
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