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Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

Intracellular generation of reactive oxygen species (ROS) via thiol-mediated reduction of copper(II) to copper(I) has been assumed as the major mechanism underlying the anticancer activity of copper(II) complexes. The aim of this study was to compare the anticancer potential of copper(II) complexes...

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Hlavní autoři: Kowol, Christian R., Heffeter, Petra, Miklos, Walter, Gille, Lars, Trondl, Robert, Cappellacci, Loredana, Berger, Walter, Keppler, Bernhard K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371635/
https://ncbi.nlm.nih.gov/pubmed/22189939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-011-0864-x
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