A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

OBJECTIVE: Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease‐modifying treatments are approved. A key therapeutic target in PD is α‐synuclein (αS), which is both genetically implicated and accumulates in Lewy bodies ri...

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Udgivet i:Ann Neurol
Main Authors: Nuber, Silke, Nam, Alice Y., Rajsombath, Molly M., Cirka, Haley, Hronowski, Xiaoping, Wang, Junmin, Hodgetts, Kevin, Kalinichenko, Liubov S., Müller, Christian P., Lambrecht, Vera, Winkler, Jürgen, Weihofen, Andreas, Imberdis, Thibaut, Dettmer, Ulf, Fanning, Saranna, Selkoe, Dennis J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756464/
https://ncbi.nlm.nih.gov/pubmed/32996158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25920
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