Pharmacodynamic monitoring of factor VIII replacement therapy in hemophilia A: Combining thrombin and plasmin generation

BACKGROUND: Clinical severity of hemophilia A (HA) varies, possibly due to interplay of many factors in the hemostatic pathway. Pharmacokinetic monitoring of factor VIII (FVIII) replacement therapy in HA patients consists of measuring FVIII activity levels and subsequent dose adjustment. The Nijmege...

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Dettagli Bibliografici
Pubblicato in:J Thromb Haemost
Autori principali: Valke, Lars L.F.G., Bukkems, Laura H., Barteling, Wideke, Laros‐van Gorkom, Britta A.P., Blijlevens, Nicole M.A., Mathôt, Ron A.A., van Heerde, Waander L., Schols, Saskia E.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
HAEMOSTASIS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756259/
https://ncbi.nlm.nih.gov/pubmed/32979031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15106
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