Pharmacodynamic monitoring of factor VIII replacement therapy in hemophilia A: Combining thrombin and plasmin generation

BACKGROUND: Clinical severity of hemophilia A (HA) varies, possibly due to interplay of many factors in the hemostatic pathway. Pharmacokinetic monitoring of factor VIII (FVIII) replacement therapy in HA patients consists of measuring FVIII activity levels and subsequent dose adjustment. The Nijmege...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Valke, Lars L.F.G., Bukkems, Laura H., Barteling, Wideke, Laros‐van Gorkom, Britta A.P., Blijlevens, Nicole M.A., Mathôt, Ron A.A., van Heerde, Waander L., Schols, Saskia E.M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
HAEMOSTASIS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756259/
https://ncbi.nlm.nih.gov/pubmed/32979031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15106
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