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Pharmacokinetic-guided dosing of factor VIII concentrate in a morbidly obese severe haemophilia A patient undergoing orthopaedic surgery
A 58-year-old morbidly obese male (body mass index: 38 kg/m(2)) with severe haemophilia A underwent total knee replacement surgery. Perioperatively, factor VIII (FVIII) levels were measured daily and maximum a posteriori (MAP) Bayesian estimation was used to calculate the individual pharmacokinetic...
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| Pubblicato in: | BMJ Case Rep |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMJ Publishing Group
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6340529/ https://ncbi.nlm.nih.gov/pubmed/30642854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr-2018-226812 |
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