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Pharmacokinetic-guided dosing of factor VIII concentrate in a morbidly obese severe haemophilia A patient undergoing orthopaedic surgery

A 58-year-old morbidly obese male (body mass index: 38 kg/m(2)) with severe haemophilia A underwent total knee replacement surgery. Perioperatively, factor VIII (FVIII) levels were measured daily and maximum a posteriori (MAP) Bayesian estimation was used to calculate the individual pharmacokinetic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMJ Case Rep
Prif Awduron: Preijers, Tim, Laros-vanGorkom, Britta AP, Mathôt, Ron AA, Cnossen, Marjon H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340529/
https://ncbi.nlm.nih.gov/pubmed/30642854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bcr-2018-226812
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