Non-full-length Water-Soluble CXCR4(QTY) and CCR5(QTY) Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors

It was posited that functionalities of GPCRs require full-length sequences that are negated by residue deletions. Here we report that significantly truncated nfCCR5(QTY) and nfCXCR4(QTY) still bind native ligands. Receptor-ligand interactions were discovered from yeast 2-hybrid screening and confirm...

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Veröffentlicht in:iScience
Hauptverfasser: Qing, Rui, Tao, Fei, Chatterjee, Pranam, Yang, Gaojie, Han, Qiuyi, Chung, Haeyoon, Ni, Jun, Suter, Bernhard P., Kubicek, Jan, Maertens, Barbara, Schubert, Thomas, Blackburn, Camron, Zhang, Shuguang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756140/
https://ncbi.nlm.nih.gov/pubmed/33376963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101670
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