QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities

Structure and function studies of membrane proteins, particularly G protein-coupled receptors and multipass transmembrane proteins, require detergents. We have devised a simple tool, the QTY code (glutamine, threonine, and tyrosine), for designing hydrophobic domains to become water soluble without...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Zhang, Shuguang, Tao, Fei, Qing, Rui, Tang, Hongzhi, Skuhersky, Michael, Corin, Karolina, Tegler, Lotta, Wassie, Asmamaw, Wassie, Brook, Kwon, Yongwon, Suter, Bernhard, Entzian, Clemens, Schubert, Thomas, Yang, Ge, Labahn, Jörg, Kubicek, Jan, Maertens, Barbara
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140526/
https://ncbi.nlm.nih.gov/pubmed/30154163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811031115
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