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Targeting Multiple Binding Sites on Cholera Toxin B with Glycomimetic Polymers Promotes Formation of Protein–Polymer Aggregates
The canonical binding site on the B subunit of cholera toxin (CTB) binds to GM1 gangliosides on host cells. However, the recently discovered noncanonical binding site on CTB with affinity for fucosylated molecules has raised the possibility that both sites can be involved in initiating intoxication....
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| Pubblicato in: | Biomacromolecules |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7755116/ https://ncbi.nlm.nih.gov/pubmed/32960582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.0c01122 |
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