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Fucose-Galactose Polymers Inhibit Cholera Toxin Binding to Fucosylated Structures and Galactose-Dependent Intoxication of Human Enteroids

[Image: see text] A promising strategy to limit cholera severity involves blockers mimicking the canonical cholera toxin ligand (CT) ganglioside GM1. However, to date the efficacies of most of these blockers have been evaluated in noncellular systems that lack ligands other than GM1. Importantly, th...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Cervin, Jakob, Boucher, Andrew, Youn, Gyusaang, Björklund, Per, Wallenius, Ville, Mottram, Lynda, Sampson, Nicole S., Yrlid, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227030/
https://ncbi.nlm.nih.gov/pubmed/32134631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00009
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