Fucose-Galactose Polymers Inhibit Cholera Toxin Binding to Fucosylated Structures and Galactose-Dependent Intoxication of Human Enteroids

[Image: see text] A promising strategy to limit cholera severity involves blockers mimicking the canonical cholera toxin ligand (CT) ganglioside GM1. However, to date the efficacies of most of these blockers have been evaluated in noncellular systems that lack ligands other than GM1. Importantly, th...

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Publicado en:ACS Infect Dis
Autores principales: Cervin, Jakob, Boucher, Andrew, Youn, Gyusaang, Björklund, Per, Wallenius, Ville, Mottram, Lynda, Sampson, Nicole S., Yrlid, Ulf
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7227030/
https://ncbi.nlm.nih.gov/pubmed/32134631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00009
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