Fucosylation and protein glycosylation create functional receptors for cholera toxin

Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates internalization of CT remains enigmatic. Here we re...

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Publicado en:eLife
Autores principales: Wands, Amberlyn M, Fujita, Akiko, McCombs, Janet E, Cervin, Jakob, Dedic, Benjamin, Rodriguez, Andrea C, Nischan, Nicole, Bond, Michelle R, Mettlen, Marcel, Trudgian, David C, Lemoff, Andrew, Quiding-Järbrink, Marianne, Gustavsson, Bengt, Steentoft, Catharina, Clausen, Henrik, Mirzaei, Hamid, Teneberg, Susann, Yrlid, Ulf, Kohler, Jennifer J
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686427/
https://ncbi.nlm.nih.gov/pubmed/26512888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09545
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