Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine‐Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme‐Linked Immunosorbent Assay–Based Method

BACKGROUND: Leucine‐rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine‐rich repeat kinase 2 function and target engagement. OBJECTIVES: Our objective was to compare c...

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Veröffentlicht in:Mov Disord
Hauptverfasser: Melachroinou, Katerina, Kang, Min Suk, Liong, Christopher, Narayan, Sushma, Levers, Najah, Joshi, Neal, Kopil, Katie, Hutten, Samantha J., Baptista, Marco A.S., Padmanabhan, Shalini, Kang, Un Jung, Stefanis, Leonidas, Alcalay, Roy N., Rideout, Hardy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2020
Schlagworte:
Regular Issue Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754308/
https://ncbi.nlm.nih.gov/pubmed/32652692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.28175
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