Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations

BACKGROUND: Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. OBJECTIVE: We examined multiple properties of LRRK2 behavior in cellular models over-expressing three sequen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Melachroinou, Katerina, Leandrou, Emmanouela, Valkimadi, Polytimi-Eleni, Memou, Anna, Hadjigeorgiou, Georgios, Stefanis, Leonidas, Rideout, Hardy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104429/
https://ncbi.nlm.nih.gov/pubmed/27832104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166053
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