Mechanisms of Caspase-Independent Neuronal Death: Energy Depletion and Free Radical Generation

Cultured rat embryonic cortical neurons undergo apoptosis when treated with the topoisomerase-I inhibitor camptothecin. Pharmacological or molecular caspase inhibition prevents apoptosis, but the neurons still die in a delayed nonapoptotic manner. Here we examine the mechanisms leading to such caspa...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Lang-Rollin, Isabelle C. J., Rideout, Hardy J., Noticewala, Manish, Stefanis, Leonidas
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2003
Subjects:
Cellular/Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741034/
https://ncbi.nlm.nih.gov/pubmed/14657158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-35-11015.2003
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