A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway

In experimental models, both in vivo and cellular, over-expression of Parkinson’s linked mutant leucine-rich repeat kinase 2 (LRRK2) is sufficient to induce neuronal death. While several cell death associated proteins have been linked to LRRK2, either as protein interactors or as putative substrates...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Antoniou, Nasia, Vlachakis, Dimitrios, Memou, Anna, Leandrou, Emmanouela, Valkimadi, Polytimi-Eleni, Melachroinou, Katerina, Re, Diane B., Przedborski, Serge, Dauer, William T., Stefanis, Leonidas, Rideout, Hardy J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823876/
https://ncbi.nlm.nih.gov/pubmed/29472595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21931-8
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