The WD40 Domain Is Required for LRRK2 Neurotoxicity

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson disease (PD). LRRK2 contains an “enzymatic core” composed of GTPase and kinase domains that is flanked by leucine-rich repeat (LRR) and WD40 protein-protein interaction domains. While kinase...

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Detalhes bibliográficos
Main Authors: Jorgensen, Nathan D., Peng, Yong, Ho, Cherry C.-Y., Rideout, Hardy J., Petrey, Donald, Liu, Peng, Dauer, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794542/
https://ncbi.nlm.nih.gov/pubmed/20041156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008463
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