Crystal structure of the WD40 domain dimer of LRRK2

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein with both a Ras of complex (ROC) domain and a kinase domain (KD) and, therefore, exhibits both GTPase and kinase activities. Human genetics studies have linked LRRK2 as a major genetic contributor to familial and sporadic Parkinson’...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Pengfei, Fan, Ying, Ru, Heng, Wang, Li, Magupalli, Venkat Giri, Taylor, Susan S., Alessi, Dario R., Wu, Hao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358694/
https://ncbi.nlm.nih.gov/pubmed/30635421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817889116
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