Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

LRRK2 plays an important role in Parkinson's disease (PD), but its biological functions are largely unknown. Here, we cloned the homolog of human LRRK2, characterized its expression, and investigated its biological functions in zebrafish. The blockage of zebrafish LRRK2 (zLRRK2) protein by morp...

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Bibliografiske detaljer
Main Authors: Sheng, Donglai, Qu, Dianbo, Kwok, Ken Hon Hung, Ng, Seok Shin, Lim, Adrian Yin Ming, Aw, Sharon Siqi, Lee, Charlie Wah Heng, Sung, Wing Kin, Tan, Eng King, Lufkin, Thomas, Jesuthasan, Suresh, Sinnakaruppan, Mathavan, Liu, Jianjun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858694/
https://ncbi.nlm.nih.gov/pubmed/20421934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000914
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