Vitamin B(12) modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection

Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson’s disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therap...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Schaffner, Adam, Li, Xianting, Gomez-Llorente, Yacob, Leandrou, Emmanouela, Memou, Anna, Clemente, Nicolina, Yao, Chen, Afsari, Farinaz, Zhi, Lianteng, Pan, Nina, Morohashi, Keita, Hua, Xiaoluan, Zhou, Ming-Ming, Wang, Chunyu, Zhang, Hui, Chen, Shu G., Elliott, Christopher J., Rideout, Hardy, Ubarretxena-Belandia, Iban, Yue, Zhenyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462009/
https://ncbi.nlm.nih.gov/pubmed/30858560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-019-0153-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados