Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine‐Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme‐Linked Immunosorbent Assay–Based Method

BACKGROUND: Leucine‐rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine‐rich repeat kinase 2 function and target engagement. OBJECTIVES: Our objective was to compare c...

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Detalhes bibliográficos
Publicado no:Mov Disord
Main Authors: Melachroinou, Katerina, Kang, Min Suk, Liong, Christopher, Narayan, Sushma, Levers, Najah, Joshi, Neal, Kopil, Katie, Hutten, Samantha J., Baptista, Marco A.S., Padmanabhan, Shalini, Kang, Un Jung, Stefanis, Leonidas, Alcalay, Roy N., Rideout, Hardy J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Regular Issue Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754308/
https://ncbi.nlm.nih.gov/pubmed/32652692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.28175
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